Chronic kidney disease and pulmonary hypertension: Progress in diagnosis and treatment

Shanshan Yuan; Shicheng Li; Jiangwen Ruan; Hui Liu; Tongmeng Jiang; Hongyan Dai

doi:10.1016/j.trsl.2024.06.003

Chronic kidney disease and pulmonary hypertension: Progress in diagnosis and treatment

Transl Res. 2024 Nov:273:16-22. doi: 10.1016/j.trsl.2024.06.003. Epub 2024 Jul 1.

Authors

Shanshan Yuan¹, Shicheng Li², Jiangwen Ruan³, Hui Liu⁴, Tongmeng Jiang⁵, Hongyan Dai⁶

Affiliations

¹ Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266011, PR China.
² Department of Cardiology, Peking Union Medical College Hospital (PUMCH), Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100730, PR China.
³ Department of Cardiology, The People's Hospital of Guangxi Zhuang Autonomous Region, Institute of Cardiovascular Sciences, Guangxi Academy of Medical Sciences, Nanning 530021, PR China.
⁴ Division of Biology and Chemistry, Paul Scherrer Institut, 5232, Villigen, Switzerland; Department of Health Sciences and Technology, ETH Zurich, 8092, Zurich, Switzerland.
⁵ Key Laboratory of Emergency and Trauma of Ministry of Education, Key Laboratory of Haikou Trauma, Key Laboratory of Hainan Trauma and Disaster Rescue, The First Affiliated Hospital, Hainan Medical University, Haikou 571199, PR China; Engineering Research Center for Hainan Bio-Smart Materials and Bio-Medical Devices, Key Laboratory of Hainan Functional Materials and Molecular Imaging, College of Emergency and Trauma, Hainan Academy of Medical Sciences, Hainan Medical University, Haikou 571199, PR China. Electronic address: jiangtongmeng@hainmc.edu.cn.
⁶ Department of Cardiology, Qingdao Municipal Hospital, Qingdao 266011, PR China. Electronic address: daihy9@163.com.

PMID: 38960282
DOI: 10.1016/j.trsl.2024.06.003

Abstract

Pulmonary hypertension (PH) is a medical condition characterized by elevated pulmonary vascular resistance and pressure, resulting from different diseases. Due to their high occurrence of PH, intricate hemodynamic classification, and frequently multifactorial cause and mechanism, individuals suffering from chronic kidney disease (CKD) are categorized as the fifth primary group of PH. Based on both domestic and international research, this article provides information on the epidemiology, risk factors, pathogenesis, and targeted drug treatment of PH associated with CKD.

Keywords: Chronic kidney disease (CKD); Pulmonary hypertension (PH), Epidemiology, Risk factors, Pathogenesis, Targeted drug therapy.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Hypertension, Pulmonary* / diagnosis
Hypertension, Pulmonary* / drug therapy
Hypertension, Pulmonary* / epidemiology
Hypertension, Pulmonary* / etiology
Hypertension, Pulmonary* / therapy
Renal Insufficiency, Chronic* / complications
Renal Insufficiency, Chronic* / diagnosis
Renal Insufficiency, Chronic* / therapy
Risk Factors