Cell type-specific polygenic burden modulates exercise effects in schizophrenia patients: further evidence on volumes of hippocampal subfields

Sergi Papiol; Lukas Roell; Isabel Maurus; Dusan Hirjak; Daniel Keeser; Andrea Schmitt; Andreas Meyer-Lindenberg; Peter Falkai

doi:10.1007/s00406-024-01841-9

Cell type-specific polygenic burden modulates exercise effects in schizophrenia patients: further evidence on volumes of hippocampal subfields

Eur Arch Psychiatry Clin Neurosci. 2024 Sep;274(6):1241-1244. doi: 10.1007/s00406-024-01841-9.

Authors

Sergi Papiol^{1

2}, Lukas Roell^{3

4}, Isabel Maurus³, Dusan Hirjak^{5

6}, Daniel Keeser^{3

4

7}, Andrea Schmitt^{8

3

9

10}, Andreas Meyer-Lindenberg^{5

6}, Peter Falkai^{8

3

10}

Affiliations

¹ Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804, Munich, Germany. sergi_papiol@psych.mpg.de.
² Institute of Psychiatric Phenomics and Genomics (IPPG), LMU University Hospital, LMU Munich, Munich, Germany. sergi_papiol@psych.mpg.de.
³ Department of Psychiatry and Psychotherapy, LMU University Hospital, LMU Munich, Munich, Germany.
⁴ NeuroImaging Core Unit Munich (NICUM), University Hospital LMU, Munich, Germany.
⁵ Medical Faculty Mannheim, Central Institute of Mental Health, Heidelberg University, Heidelberg, Germany.
⁶ German Centre for Mental Health (DZPG), Partner site Mannheim/Heidelberg/Ulm, Germany.
⁷ Munich Center for Neurosciences (MCN), LMU Munich, Munich, Germany.
⁸ Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804, Munich, Germany.
⁹ Laboratory of Neuroscience (LIM27), Institute of Psychiatry, University of Sao Paulo, São Paulo, Brazil.
¹⁰ German Centre for Mental Health (DZPG), Partner site Munich/Augsburg, Germany.

No abstract available

Keywords: Hippocampus; Oligodendrocyte precursor cell; Physical activity; Polygenic risk score; Schizophrenia.

Publication types

Letter
Editorial

MeSH terms

Adult
Exercise* / physiology
Female
Hippocampus* / pathology
Hippocampus* / physiopathology
Humans
Magnetic Resonance Imaging
Male
Multifactorial Inheritance
Schizophrenia* / genetics
Schizophrenia* / pathology
Schizophrenia* / physiopathology