The diagnostic value of serum hepcidin in acute appendicitis

Ulus Travma Acil Cerrahi Derg. 2024 Jul;30(7):480-486. doi: 10.14744/tjtes.2024.23187.


Background: Acute appendicitis (AA) is the primary cause of acute abdomen in patients presenting to the emergency department with abdominal pain. Limited studies have explored the relationship between serum hepcidin levels and AA. This study aimed to measure serum hepcidin levels in patients undergoing surgery with a preliminary diagnosis of AA and to assess whether these levels can serve as a biochemical marker for diagnosing AA.

Methods: This study included patients aged 18 or older who presented to the emergency department between April 2018 and May 2019 and underwent surgery with a diagnosis of AA. The cohort comprised 94 patients with surgical pathology results compatible with AA (Group A), 16 patients with results not compatible with AA (Group B), and 42 healthy controls. Serum hepcidin levels were measured from venous blood samples.

Results: Mean hepcidin levels were 1750±285 pg/mL in Group A, 1349±381 pg/mL in Group B, and 1066±225 pg/mL in the control group. Statistically significant differences in serum hepcidin levels were observed between Group A and the control group (p<0.05).

Conclusion: Hepcidin levels were significantly higher in patients with AA compared to both the control group and patients with surgically confirmed non-AA pathology. Therefore, hepcidin may serve as a useful adjunct in diagnosing acute appendicitis.

MeSH terms

  • Acute Disease
  • Adolescent
  • Adult
  • Aged
  • Appendicitis* / blood
  • Appendicitis* / diagnosis
  • Appendicitis* / surgery
  • Biomarkers* / blood
  • Case-Control Studies
  • Female
  • Hepcidins* / blood
  • Humans
  • Male
  • Middle Aged
  • Young Adult


  • Hepcidins
  • Biomarkers