Squamous metaplasia of the breast. An ultrastructural and immunologic evaluation

Am J Clin Pathol. 1985 Oct;84(4):530-3. doi: 10.1093/ajcp/84.4.530.

Abstract

Squamous metaplasia in the breast is rare. This case of an intracystic papilloma of the breast with prominent squamous change was found by electron microscopy and immunohistochemistry to contain evidence of squamous differentiation within myoepithelial cells. The findings suggest that squamous metaplasia of the breast may result from myoepithelial cell differentiation in a manner analogous to the development of squamous lesions in the cervix and salivary gland. The possible relationship of this finding to the development of squamous lesions of the breast is discussed.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Breast Neoplasms / pathology
  • Breast Neoplasms / ultrastructure*
  • Carcinoma, Squamous Cell / pathology
  • Carcinoma, Squamous Cell / ultrastructure*
  • Cell Differentiation
  • Female
  • Humans
  • Immunoenzyme Techniques
  • Metaplasia
  • Neoplastic Stem Cells