Prophylaxis for acute stress ulcers. Antacids or cimetidine

Am Surg. 1985 Sep;51(9):545-7.

Abstract

Two hundred and forty-nine patients are divided into four homogenous groups to compare the efficacy of Cimetidine versus antacids, as well as the mode of delivery--bolus versus continuous drip--in the prophylaxis of acute hemorrhagic gastritis in critically ill patients. Antacids were favored over Cimetidine, and the continuous drip was the superior method with both drugs.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial

MeSH terms

  • Acute Disease
  • Antacids / administration & dosage
  • Antacids / therapeutic use*
  • Cimetidine / administration & dosage
  • Cimetidine / therapeutic use*
  • Clinical Trials as Topic
  • Humans
  • Intubation, Gastrointestinal
  • Peptic Ulcer / etiology
  • Peptic Ulcer / prevention & control*
  • Peptic Ulcer Hemorrhage / prevention & control
  • Peptic Ulcer Hemorrhage / surgery
  • Premedication
  • Prospective Studies
  • Random Allocation
  • Stress, Physiological / complications*
  • Time Factors

Substances

  • Antacids
  • Cimetidine