Unmasking immune suppression

Science. 2024 Jul 12;385(6705):140-142. doi: 10.1126/science.adq5196. Epub 2024 Jul 11.

Authors

Jason R Pitarresi¹, Katherine A Fitzgerald²

Affiliations

¹ Division of Hematology-Oncology, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.
² Division of Innate Immunity, Department of Medicine, University of Massachusetts Chan Medical School, Worcester, MA, USA.

PMID: 38991086
DOI: 10.1126/science.adq5196

Abstract

Inhibition of a mutated metabolic enzyme puts the sting back in antitumor immunity.

Publication types

Comment

MeSH terms

Animals
Humans
Immune Evasion* / genetics
Immune Tolerance / genetics
Isocitrate Dehydrogenase* / genetics
Isocitrate Dehydrogenase* / metabolism
Mice
Neoplasms* / genetics
Neoplasms* / immunology
Tumor Escape* / genetics

Substances

Isocitrate Dehydrogenase