Combatting superbugs using the evolutionary record of microbial warfare

Arjun S Raman

doi:10.1016/j.chom.2024.06.001

Combatting superbugs using the evolutionary record of microbial warfare

Cell Host Microbe. 2024 Jul 10;32(7):1037-1039. doi: 10.1016/j.chom.2024.06.001.

Author

Arjun S Raman¹

Affiliation

¹ Department of Pathology, University of Chicago, Chicago, IL, USA; Center for the Physics of Evolving Systems, University of Chicago, Chicago, IL, USA; Duchossois Family Institute, University of Chicago, Chicago, IL, USA. Electronic address: araman@bsd.uchicago.edu.

PMID: 38991497
DOI: 10.1016/j.chom.2024.06.001

Abstract

New therapies to treat multi-drug-resistant (MDR) pathogens are needed. Santos-Júnior et al. discover new antimicrobials by leveraging the history of warfare within microbial communities. This study in Cell highlights the immense power of combining large biological databases with emerging computational methods, creating a key resource (AMPSphere) to be used for treating superbugs.

MeSH terms

Anti-Bacterial Agents* / pharmacology
Bacteria / drug effects
Bacteria / genetics
Computational Biology / methods
Drug Resistance, Multiple, Bacterial / genetics
Humans

Substances

Anti-Bacterial Agents