Specific inhibition of macrophage migration inhibition factor by fucosylated glycolipid RM

J Biochem. 1979 Sep;86(3):773-6. doi: 10.1093/oxfordjournals.jbchem.a132583.


The effects of glycolipids on the interaction of the MIF (migration inhibition factor) with rat macrophages were examined using a migration inhibition assay system. MIF activity was specifically blocked by fucosylated Glycolipid RM [Gal alpha 1-3Gal(2-1 alpha Fuc) beta 1-3GalNAc beta 1-3Gal beta 1-4Glc beta 1-1ceramide, (1978) J. Biochem. 83, 85-90], but not by Cytolipin R, hematoside, or blood group B active glycolipid [Gal alpha 1-3Gal(2-1 alpha Fuc) beta 1-4GlcNAc beta 1-3Gal beta 1-4Glc beta 1-1ceramide]. Inhibition of MIF activity was proportional to the concentration of Glycolipid RM. These findings suggest that Glycolipid RM acts as a receptor for MIF.

MeSH terms

  • Animals
  • Fucose / pharmacology
  • G(M3) Ganglioside / pharmacology
  • Globosides / pharmacology*
  • Glycolipids / pharmacology
  • Glycosphingolipids / pharmacology*
  • Macrophage Migration-Inhibitory Factors / antagonists & inhibitors*
  • Male
  • Rats


  • G(M3) Ganglioside
  • Globosides
  • Glycolipids
  • Glycosphingolipids
  • Macrophage Migration-Inhibitory Factors
  • Fucose