Abstract
The pharmacokinetics of TCAs are reviewed with particular emphasis on nortriptyline, the agent most extensively studied. The clinical uses of TCA plasma level-response studies are discussed in relationship to rational dosage adjustment to increase response rates and avoid iatrogenic toxicity. Other important topics discussed include the issue of active metabolites, single-dose prediction studies, and special considerations in treating the elderly and the medically ill.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Age Factors
-
Aged
-
Antidepressive Agents, Tricyclic / blood
-
Antidepressive Agents, Tricyclic / metabolism
-
Antidepressive Agents, Tricyclic / therapeutic use
-
Depressive Disorder / drug therapy*
-
Depressive Disorder / metabolism
-
Half-Life
-
Humans
-
Kinetics
-
Middle Aged
-
Nortriptyline / analogs & derivatives
-
Nortriptyline / blood
-
Nortriptyline / metabolism*
-
Nortriptyline / therapeutic use
Substances
-
Antidepressive Agents, Tricyclic
-
10-hydroxynortriptyline
-
Nortriptyline