Ethanol decreases glucose utilization in healthy man

J Clin Endocrinol Metab. 1985 Nov;61(5):941-5. doi: 10.1210/jcem-61-5-941.

Abstract

The effect of ethanol on glucose utilization during hyperinsulinemia was studied by the euglycemic clamp technique. Normal subjects were given 1 g ethanol/kg body weight for 210 min (oral priming dose of 0.67 g/kg followed by iv infusion of 0.33 g/kg) or 0.9% saline. Insulin infusion, started 90 min after the beginning of ethanol administration, resulted in a mean plasma insulin concentration of 87 +/- 5 (SEM) mU/liter. Plasma glucose was maintained at 5.2 mmol/liter. The rate of glucose metabolism was 23% lower during ethanol (7.1 +/- 0.1 mg/kg X min) than during the control (9.0 +/- 0.8 mg/kg X min) experiment (P less than 0.001). During hyperinsulinemia blood lactate concentrations rose in the control study but this change was abolished by ethanol. The insulin-induced fall of serum triglyceride levels was also inhibited by ethanol. It is concluded that acute intake of alcohol in moderate doses induces insulin resistance.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Blood Glucose / analysis
  • Ethanol / blood
  • Ethanol / pharmacology*
  • Fatty Acids, Nonesterified / blood
  • Glucagon / blood
  • Glucose / metabolism*
  • Growth Hormone / blood
  • Humans
  • Hydrocortisone / blood
  • Insulin / blood
  • Lactates / blood
  • Male
  • Pyruvates / blood
  • Pyruvic Acid
  • Triglycerides / blood

Substances

  • Blood Glucose
  • Fatty Acids, Nonesterified
  • Insulin
  • Lactates
  • Pyruvates
  • Triglycerides
  • Ethanol
  • Pyruvic Acid
  • Growth Hormone
  • Glucagon
  • Glucose
  • Hydrocortisone