Cognition falters at ~4 Hz in Parkinson's disease

Nandakumar S Narayanan; Zahra Jourahmad; Rachel C Cole; James F Cavanagh

doi:10.1016/j.tics.2024.06.002

Cognition falters at ~4 Hz in Parkinson's disease

Trends Cogn Sci. 2024 Sep;28(9):789-791. doi: 10.1016/j.tics.2024.06.002. Epub 2024 Jul 12.

Authors

Nandakumar S Narayanan¹, Zahra Jourahmad², Rachel C Cole³, James F Cavanagh⁴

Affiliations

¹ Department of Neurology, University of Iowa, Iowa City, IA 52242, USA. Electronic address: nandakumar-narayanan@uiowa.edu.
² Department of Neurosurgery, University of Iowa, Iowa City, IA 52242, USA.
³ Department of Neurology, University of Minnesota, Minneapolis, MN 55455, USA.
⁴ Department of Psychology, University of New Mexico, Albuquerque, NM 87109, USA.

Abstract

Cognitive impairments are common in Parkinson's disease (PD). We have linked this deficit to attenuated midfrontal 1-8-Hz activity that fails to engage cortical cognitive networks. We discuss the consequences of these impairments and how they might be leveraged for PD-specific neurophysiological markers and for novel brain stimulation paradigms.

Keywords: Parkinson’s disease; dopamine; prefrontal cortex.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Brain / physiopathology
Brain Waves / physiology
Cognition / physiology
Cognitive Dysfunction* / etiology
Cognitive Dysfunction* / physiopathology
Humans
Parkinson Disease* / complications
Parkinson Disease* / physiopathology

Abstract

Publication types

MeSH terms

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