Antiestrogen effects on human blood lymphocyte subpopulations in vitro

J Clin Lab Immunol. 1985 May;17(1):33-5.


Human blood lymphocytes were incubated for 24 hr in medium containing various therapeutic concentrations of the antiestrogenic drug Tamoxifen. This treatment resulted in a diminished expression of C'3-receptors on the cells as detected by a rosette technique (EAC-rosettes). The expression of membrane receptors for sheep red blood cells (SRBC) was not changed under the experimental conditions used.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Animals
  • Erythrocytes / immunology
  • Female
  • Humans
  • In Vitro Techniques
  • Lymphocytes / classification
  • Lymphocytes / drug effects*
  • Macrophage-1 Antigen
  • Middle Aged
  • Receptors, Complement / drug effects
  • Receptors, Complement / metabolism
  • Receptors, Immunologic / drug effects
  • Rosette Formation
  • Sheep
  • Tamoxifen / pharmacology*


  • Macrophage-1 Antigen
  • Receptors, Complement
  • Receptors, Immunologic
  • Tamoxifen