Aspartame use by persons with diabetes

Diabetes Care. 1985 Sep-Oct;8(5):415-7. doi: 10.2337/diacare.8.5.415.


Sixty-two subjects having either insulin-dependent or non-insulin-dependent diabetes completed a randomized, double-blind study comparing effects of aspartame or a placebo on blood glucose control. Twenty-nine subjects consumed 2.7 g aspartame per day for 18 wk, given as aspartame-containing capsules with meals, while 33 subjects took identical appearing placebo capsules. After 18 wk, no changes were seen in fasting or 2-h postprandial blood glucose levels or glycohemoglobin levels in either the aspartame- or placebo-treated groups. Adverse reactions were no more common in the group taking aspartame. We conclude that use of aspartame as a low-calorie sweetener does not adversely affect glycemic control of persons with diabetes.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aspartame / adverse effects*
  • Blood Glucose / metabolism
  • Clinical Trials as Topic
  • Diabetes Mellitus / blood
  • Diabetes Mellitus / diet therapy*
  • Dipeptides / adverse effects*
  • Double-Blind Method
  • Glycated Hemoglobin A / analysis
  • Humans
  • Middle Aged
  • Random Allocation
  • Safety


  • Blood Glucose
  • Dipeptides
  • Glycated Hemoglobin A
  • Aspartame