Clonidine hydrochloride--a safe and effective antihypertensive agent in pregnancy

Obstet Gynecol. 1985 Nov;66(5):634-8.


A prospective, double-blind, randomized controlled trial was carried out, comparing alpha-methyldopa and clonidine hydrochloride in 100 pregnant women with hypertension. There was no difference in hypotensive effect or reported maternal side effects with either agent. There was one neonatal loss in each group (98% survival). Neither drug caused clinically significant hypotension nor rebound hypertension in the neonates. Clonidine hydrochloride, like methyldopa, appears to be a safe antihypertensive agent in pregnancy.

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Apgar Score
  • Blood Pressure
  • Clinical Trials as Topic
  • Clonidine / therapeutic use*
  • Double-Blind Method
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Infant, Newborn
  • Methyldopa / therapeutic use*
  • Pregnancy
  • Pregnancy Complications, Cardiovascular / drug therapy*
  • Prospective Studies
  • Random Allocation


  • Methyldopa
  • Clonidine