Recent advances in anti-inflammation via AMPK activation

Yihua Xu; Lan Bai; Xinwei Yang; Jianli Huang; Jie Wang; Xianbo Wu; Jianyou Shi

doi:10.1016/j.heliyon.2024.e33670

Recent advances in anti-inflammation via AMPK activation

Heliyon. 2024 Jun 26;10(13):e33670. doi: 10.1016/j.heliyon.2024.e33670. eCollection 2024 Jul 15.

Authors

Yihua Xu¹, Lan Bai^{2

3}, Xinwei Yang⁴, Jianli Huang⁵, Jie Wang⁵, Xianbo Wu⁴, Jianyou Shi^{2

3}

Affiliations

¹ School of Basic Medical Science, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
² Department of Pharmacy, Personalized Drug Therapy Key Laboratory of Sichuan Province, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, Sichuan, China.
³ The State Key Laboratory of Southwestern Chinese Medicine Resources, Department of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, Sichuan, China.
⁴ School of Sports Medicine and Health, Chengdu Sport University, Chengdu, Sichuan, China.
⁵ Guizhou University of Traditional Chinese Medicine, Guiyang, Guizhou, China.

Abstract

Inflammation is a complex physiological phenomenon, which is the body's defensive response, but abnormal inflammation can have adverse effects, and many diseases are related to the inflammatory response. AMPK, as a key sensor of cellular energy status, plays a crucial role in regulating cellular energy homeostasis and glycolipid metabolism. In recent years, the anti-inflammation effect of AMPK and related signalling cascade has begun to enter everyone's field of vision - not least the impact on metabolic diseases. A great number of studies have shown that anti-inflammatory drugs work through AMPK and related pathways. Herein, this article summarises recent advances in compounds that show anti-inflammatory effects by activating AMPK and attempts to comment on them.

Keywords: AMPK; Inflammasome; Inflammation; NF-κB; SIRT; Treatment.

Publication types

Review