Low cyclosporin A blood levels and acute graft rejection in a renal transplant recipient during rifampin treatment

Am J Nephrol. 1985;5(5):385-7. doi: 10.1159/000166968.


Cyclosporin A trough blood levels were unusually low during rifampin treatment in a kidney transplant patient. Simultaneously, acute graft rejection occurred. Pharmacokinetic investigation revealed a rapid turnover of cyclosporin A leading to low blood levels. Cessation of rifampin therapy reversed these changes. Rifampin substantially reduces the bioavailability of cyclosporin A and should not be used in transplant recipients on cyclosporin A.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Biological Availability
  • Cyclosporins / blood*
  • Cyclosporins / therapeutic use
  • Female
  • Graft Rejection*
  • Humans
  • Kidney Failure, Chronic / complications
  • Kidney Failure, Chronic / drug therapy
  • Kidney Failure, Chronic / surgery
  • Kidney Transplantation*
  • Rifampin / adverse effects*
  • Rifampin / therapeutic use
  • Tuberculosis, Pulmonary / complications
  • Tuberculosis, Pulmonary / drug therapy


  • Cyclosporins
  • Rifampin