Evaluation of an in-use chest CT protocol in lung cancer screening - A single institutional study

Salma Naimi; Mercy Afadzi Tetteh; Haseem Ashraf; Safora Johansen

doi:10.1177/20584601241256005

Evaluation of an in-use chest CT protocol in lung cancer screening - A single institutional study

Acta Radiol Open. 2024 Jul 1;13(7):20584601241256005. doi: 10.1177/20584601241256005. eCollection 2024 Jul.

Authors

Salma Naimi¹, Mercy Afadzi Tetteh², Haseem Ashraf^{2

3}, Safora Johansen^{1

4

5}

Affiliations

¹ Health faculty, Oslo Metropolitan University, Oslo, Norway.
² Department of Diagnostic Imaging, Akershus University Hospital, Lørenskog, Norway.
³ Division of Medicine and Laboratory Sciences, University of Oslo, Oslo, Norway.
⁴ Department of Cancer Treatment, Oslo University Hospital, Oslo, Norway.
⁵ Health and Social Sciences, Cluster, Singapore Institution of Technology, Singaporee.

Abstract

Background: Lung cancer is the most common cause of cancer-related death worldwide and therefore there has been a growing demand for low-dose computed tomography (LDCT) protocols.

Purpose: To investigate and evaluate the dose and image quality of patients undergoing lung cancer screening (LCS) using LDCT in Norway.

Materials and methods: Retrospective dosimetry data, volumetric CT dose index (CTDI_vol) and dose-length product (DLP), from 70 average-size and 70 large-size patients who underwent LDCT scan for LCS were included in the survey. Effective dose and size-specific dose were calculated for each examination and were compared with the American Association of Physicists in Medicine (AAPM) requirement. For a quantitative image quality analysis, noise, signal-to-noise ratio (SNR), and contrast-to-noise ratio (CNR) were determined for different regions in the chest with two iterative reconstruction techniques, iDose and Iterative Model Reconstruction. Differences in dose and image quality between average-size and large-size patients were evaluated by Independent sample t test, and Wilcoxon signed rank test within the same patient group.

Results: The independent sample t test revealed significant differences (p < .05) in dose values between average-size and large-size patients. Mean CTDI_vol and DLP for average-size patients were 2.8 mGy and 115 mGy.cm, respectively, with appropriate increment for the large-size patients. Image quality (image noise, SNR, and CNR) did not significantly differ between patient groups when images were reconstructed with a model based iterative reconstruction algorithm.

Conclusion: The screening protocol assessed in this study resulted in CTDI_vol values that were compliant with AAPM recommendation. No significant differences in objective image quality were found between patient groups.

Keywords: American Association of Physicists in Medicine; CT dose index; Low-dose CT; lung cancer screening.