The therapeutic actions of theophylline in preterm ventilated infants

Early Hum Dev. 1985 Oct;12(1):15-22. doi: 10.1016/0378-3782(85)90132-x.


40 preterm, ventilated infants (gestational ages 24-33 weeks) were entered into a double-blind randomised trial to assess the effect of oral theophylline on lung function and ventilator dependence. Theophylline administration was associated with a significant improvement in compliance (P less than 0.05) and hastened weaning from ventilation (P less than 0.01).

Publication types

  • Clinical Trial
  • Comparative Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Administration, Oral
  • Clinical Trials as Topic
  • Double-Blind Method
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature*
  • Lung Compliance
  • Respiration, Artificial*
  • Theophylline / administration & dosage
  • Theophylline / therapeutic use*


  • Theophylline