The c-myc oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice

Nature. 1985 Dec 12-18;318(6046):533-8. doi: 10.1038/318533a0.

Abstract

Transgenic mice bearing the cellular myc oncogene coupled to the immunoglobulin mu or kappa enhancer frequently develop a fatal lymphoma within a few months of birth. Since the tumours represent represent both immature and mature B lymphocytes, constitutive c-myc expression appears to be highly leukaemogenic at several stages of B-cell maturation. These myc mice should aid study of lymphoma development, B-cell ontogeny and immunoglobulin regulation.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • B-Lymphocytes / pathology
  • Cell Differentiation
  • DNA, Recombinant
  • Enhancer Elements, Genetic*
  • Gene Expression Regulation
  • Genes
  • Genes, Regulator*
  • Immunoglobulins / genetics*
  • Lymphoma / genetics*
  • Mice
  • Oncogenes*
  • Proto-Oncogene Proteins / genetics*
  • Recombination, Genetic
  • Transcription, Genetic

Substances

  • DNA, Recombinant
  • Immunoglobulins
  • Proto-Oncogene Proteins