Delayed Induction of Noninflammatory SARS-CoV-2 Spike-Specific IgG4 Antibodies Detected 1 Year After BNT162b2 Vaccination in Children

Pediatr Infect Dis J. 2024 Dec 1;43(12):1200-1203. doi: 10.1097/INF.0000000000004488. Epub 2024 Jul 30.

Abstract

Humoral immune responses after BNT162b2 vaccination are predominantly composed of immunoglobulin (Ig) G1 and IgG3 subclass antibodies. As previously described in adults, S1-specific and receptor-binding domain-specific IgG4 levels increase significantly 1 year after the second BNT162b2 vaccination in children 5-11 years of age. Understanding mRNA vaccine-specific IgG4 responses in all age groups is crucial as more mRNA vaccines will reach licensure in the coming years.

Keywords: IgG subclass; IgG4; SARS-CoV-2; children; immune response; mRNA vaccine; noninflammatory; system immunology.

MeSH terms

  • Antibodies, Viral* / blood
  • Antibodies, Viral* / immunology
  • BNT162 Vaccine / immunology
  • COVID-19 Vaccines* / administration & dosage
  • COVID-19 Vaccines* / immunology
  • COVID-19* / immunology
  • COVID-19* / prevention & control
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Immunoglobulin G* / blood
  • Immunoglobulin G* / immunology
  • Male
  • SARS-CoV-2* / immunology
  • Spike Glycoprotein, Coronavirus* / immunology
  • Vaccination

Substances

  • Immunoglobulin G
  • BNT162 Vaccine
  • Antibodies, Viral
  • Spike Glycoprotein, Coronavirus
  • spike protein, SARS-CoV-2
  • COVID-19 Vaccines