[Polyploidizing Mitoses and the Biological Meaning of Polyploidy in Liver Cells]

Tsitologiia. 1979 Dec;21(12):1427-37.
[Article in Russian]

Abstract

The ontogenetic polyploidization of hepatocytes is regarded, within which normal mitoses are changed to polyploidizing mitoses, and diploid hepatocytes transform into polyploid mono- and binuclear cells. A new hypothesis is put forward of the biological significance of the liver cell polyploidy. The hypothesis takes into account a high level of spontaneous chromosomal aberrations in mitotic hepatocytes. The chromosome structural changes interfere with mitosis resulting in the chromosomal imbalance. Polyploidy bestows for hepatocytes a tolerance towards a chromosomal imbalance. Some implications of the hypothesis are discussed: unbalanced genome of hepatocytes after the treatment with mutagens and mitotic stimulators; the reasons of liver cell polyploidy differences in mammalian species; mechanisms of radioresistance of hepatocytes. Chromosomal imbalance of polyploid hepatocytes is assumed to be the basis for wome chronic liver diseases in man.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Animals
  • Cell Division
  • Cells, Cultured
  • Chromosome Aberrations
  • Chronic Disease
  • DNA / genetics
  • Diploidy
  • Genotype
  • Humans
  • In Vitro Techniques
  • Liver / cytology*
  • Liver / growth & development
  • Liver / ultrastructure
  • Liver Diseases / etiology
  • Liver Regeneration
  • Mitosis*
  • Polyploidy*
  • Radiation Tolerance
  • Species Specificity

Substances

  • DNA