Nanomaterials for bone metastasis

Xinyan Hao; Buchan Jiang; Junyong Wu; Daxiong Xiang; Zijian Xiong; Chenbei Li; Zhaoqi Li; Shasha He; Chao Tu; Zhihong Li

doi:10.1016/j.jconrel.2024.07.067

Nanomaterials for bone metastasis

J Control Release. 2024 Sep:373:640-651. doi: 10.1016/j.jconrel.2024.07.067. Epub 2024 Aug 1.

Authors

Xinyan Hao¹, Buchan Jiang², Junyong Wu³, Daxiong Xiang³, Zijian Xiong⁴, Chenbei Li², Zhaoqi Li², Shasha He⁵, Chao Tu⁶, Zhihong Li⁷

Affiliations

¹ Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Xiangya School of Medicine, Central South University, Changsha, Hunan 410011, China; Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
² Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
³ Department of Pharmacy, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
⁴ Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Xiangya School of Medicine, Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China.
⁵ Department of Oncology, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China. Electronic address: heshasha611@csu.edu.cn.
⁶ Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Changsha Medical University, Changsha 410219, China. Electronic address: tuchao@csu.edu.cn.
⁷ Department of Orthopaedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, China; Shenzhen Research Institute of Central South University, Guangdong 518063, China; FuRong Laboratory, Changsha 410078, Hunan, China. Electronic address: lizhihong@csu.edu.cn.

PMID: 39084467
DOI: 10.1016/j.jconrel.2024.07.067

Abstract

Bone metastasis, a prevalent occurrence in primary malignant tumors, is often associated with a grim prognosis. The bone microenvironment comprises various coexisting cell types, working together in a coordinated manner. This dynamic microenvironment plays a pivotal role in the initiation and progression of bone metastases. While cancer therapies have made advancements, the available options for addressing bone metastases remain insufficient. The advent of nanotechnology has ushered in a new era for managing and preventing bone metastases because of the physicochemical and adaptable advantages of nanoplatforms. In this review, we make an introduction of the underlying mechanisms and the current clinical therapies of bone metastases, highlighting the advances of intelligent nanosystems that can stimulate vascular regeneration, promote bone regeneration, eliminate tumor cells, minimize bone damage, and expedite bone healing. The innovation surrounding bone-targeting nanoplatforms presents a fresh approach to the theranostics of bone metastases.

Keywords: Bone metastasis; Bone microenvironment; Drug delivery; Nanomaterials; Nanosystems.

Publication types

Review

MeSH terms

Animals
Bone Neoplasms* / secondary
Bone Regeneration
Humans
Nanostructures* / administration & dosage
Nanostructures* / therapeutic use
Tumor Microenvironment