Use of a Species-Specific Antibody for Demonstrating Mouse Neurons Transplanted to Rat Brains

Neurosci Lett. 1985 Oct 24;61(1-2):221-6. doi: 10.1016/0304-3940(85)90428-8.

Abstract

A cell surface monoclonal antibody specific for mouse central nervous system neurons was used to identify mouse tissue transplanted to neonatal rat brains. Neuronal cell bodies and processes were stained in the transplants. Immature axons were stained growing out of the transplants into the host brain; and in mature brains unmyelinated axons and terminal plexuses were demonstrated. The technique allows a variety of studies to be performed on transplant-host interactions, especially in circumstances where the two are closely apposed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibodies, Monoclonal*
  • Antigens, Surface*
  • Glycoproteins / immunology*
  • Immunoenzyme Techniques
  • Mice
  • Mice, Inbred C57BL
  • Microscopy, Electron
  • Nerve Tissue / immunology
  • Nerve Tissue / transplantation*
  • Rats
  • Species Specificity

Substances

  • Antibodies, Monoclonal
  • Antigens, Surface
  • Glycoproteins