Cisplatin: a review of clinical applications and renal toxicity

Pharm Weekbl Sci. 1985 Dec 13;7(6):237-44. doi: 10.1007/BF01959196.

Abstract

In reviewing the literature about the clinical application of cis-diamminedichloroplatinum(II) (cisplatin) it can be concluded that the availability of cisplatin has been an important advance in cancer chemotherapy; especially in patients with disseminated testicular carcinoma and ovarian cancer cisplatin-based combinations are the first choice treatment. Our own investigations of the nature of the main form of toxicity of cisplatin, the nephrotoxicity, are mentioned and methods of its prevention are summarized.

Publication types

  • Review

MeSH terms

  • Cisplatin / administration & dosage
  • Cisplatin / adverse effects
  • Cisplatin / therapeutic use*
  • Female
  • Humans
  • Kidney Diseases / chemically induced*
  • Kidney Diseases / prevention & control
  • Male
  • Neoplasms / drug therapy*

Substances

  • Cisplatin