Design and decoration of copper nanoparticles into lignosulfonate-starch bionanocomposite: Characterization and evaluation of its therapeutic properties on burn wound

Int J Biol Macromol. 2024 Oct;278(Pt 2):134389. doi: 10.1016/j.ijbiomac.2024.134389. Epub 2024 Aug 6.

Abstract

In this report, eco-friendly synthesis for the production of copper nanoparticles by employing the sodium lignosulfonate (NaLS) mixed starch composite (NaLS-Starch/Cu NPs). NaLS-Starch mixed hydrogel has notable reducing and stabilizing potential for preparation of Cu nanoparticles. Characterization of NaLS-Starch/Cu NPs bionanocomposite was subjected to analysis of spectroscopic and microscopic techniques, including FE-SEM, TEM, EDS-elemental mapping, particle size distribution, XRD and ICP. TEM images displayed the spherical structured NaLS-Starch/Cu NPs, averaging 5-10 nm size. NaLS-Starch/Cu NPs were applied to cure the induced burn wounds in 60 Wistar rats. A group was considered as control group. The animals were treated with basal, tetracycline 3 % and NaLS-Starch/Cu NPs 3 % for 30 days and the treatment efficacy was determined according to the burn wound area reduction and molecular and histological characteristics. Taken together, these results support therapeutic use of NaLS-Starch/Cu NPs as potent ointment that may be proposed for burn wound healing. NaLS-Starch/Cu NPs ointment increased the levels of platelet-derived growth factors (PDGF) and fibroblast growth factor (bFGF). The mean wound surface, in all groups treated by NaLS-Starch/Cu NPs was larger than control group.

Keywords: Characterization; Copper nanoparticles; NaLS-starch/Cu NPs; Wound.

MeSH terms

  • Animals
  • Burns* / drug therapy
  • Copper* / chemistry
  • Lignin* / analogs & derivatives
  • Lignin* / chemistry
  • Lignin* / pharmacology
  • Male
  • Metal Nanoparticles* / chemistry
  • Nanocomposites* / chemistry
  • Rats
  • Rats, Wistar*
  • Starch* / analogs & derivatives
  • Starch* / chemistry
  • Wound Healing* / drug effects

Substances

  • Starch
  • Copper
  • Lignin
  • lignosulfuric acid