Pathogenic mechanisms and latest therapeutic approaches for radiation-induced lung injury: A narrative review

Sitong Chang; Jincai Lv; Xuanzhong Wang; Jing Su; Chenbin Bian; Zhuangzhuang Zheng; Huiyuan Yu; Jindian Bao; Ying Xin; Xin Jiang

doi:10.1016/j.critrevonc.2024.104461

Pathogenic mechanisms and latest therapeutic approaches for radiation-induced lung injury: A narrative review

Crit Rev Oncol Hematol. 2024 Oct:202:104461. doi: 10.1016/j.critrevonc.2024.104461. Epub 2024 Aug 3.

Authors

Sitong Chang¹, Jincai Lv², Xuanzhong Wang³, Jing Su⁴, Chenbin Bian⁵, Zhuangzhuang Zheng⁶, Huiyuan Yu⁷, Jindian Bao⁸, Ying Xin⁹, Xin Jiang¹⁰

Affiliations

¹ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China. Electronic address: changst22@mails.jlu.edu.cn.
² Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China. Electronic address: lvjincai@jlu.edu.cn.
³ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China. Electronic address: wangxuanzhong@jlu.edu.cn.
⁴ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China. Electronic address: jingsu21@mails.jlu.edu.cn.
⁵ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China. Electronic address: biancb21@mails.jlu.edu.cn.
⁶ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China. Electronic address: zhengzz2715@mails.jlu.edu.cn.
⁷ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China. Electronic address: hyyu22@mails.jlu.edu.cn.
⁸ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China. Electronic address: baojd22@mails.jlu.edu.cn.
⁹ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Key Laboratory of Pathobiology, Ministry of Education, Jilin University, Changchun 130021, China. Electronic address: xiny@jlu.edu.cn.
¹⁰ Jilin Provincial Key Laboratory of Radiation Oncology & Therapy, The First Hospital of Jilin University and College of Basic Medical Science, Jilin University, Changchun, China; Department of Radiation Oncology, the First Hospital of Jilin University, Changchun 130021, China; NHC Key Laboratory of Radiobiology, School of Public Health of Jilin University, Changchun 130021, China. Electronic address: jiangx@jlu.edu.cn.

PMID: 39103129
DOI: 10.1016/j.critrevonc.2024.104461

Abstract

The treatment of thoracic tumors with ionizing radiation can cause radiation-induced lung injury (RILI), which includes radiation pneumonitis and radiation-induced pulmonary fibrosis. Preventing RILI is crucial for controlling tumor growth and improving quality of life. However, the serious adverse effects of traditional RILI treatment methods remain a major obstacle, necessitating the development of novel treatment options that are both safe and effective. This review summarizes the molecular mechanisms of RILI and explores novel treatment options, including natural compounds, gene therapy, nanomaterials, and mesenchymal stem cells. These recent experimental approaches show potential as effective prevention and treatment options for RILI in clinical practice.

Keywords: Fibrosis; Mesenchymal stem cells; Pneumonitis; Radiation-induced lung injury; Radiotherapy; Therapy.

Publication types

Review

MeSH terms

Animals
Genetic Therapy / methods
Humans
Lung Injury* / etiology
Lung Injury* / therapy
Radiation Injuries* / etiology
Radiation Injuries* / therapy
Radiation Pneumonitis / etiology
Radiation Pneumonitis / therapy