Hyperaminoacidaemia reduces insulin-mediated glucose disposal in healthy man

Diabetologia. 1985 Nov;28(11):870-2. doi: 10.1007/BF00291080.

Abstract

To determine whether hyperaminoacidaemia may modify insulin-mediated glucose disposal, normal subjects were studied with the euglycaemic glucose-clamp technique, with or without an amino acid infusion, at a rate sufficient to duplicate the plasma concentration of most amino acids. Steady-state glucose infusion rates to maintain euglycaemia were 36% lower during hyperaminoacidaemia (7.3 +/- 1.0 versus 11.4 +/- 0.8 mg X kg-1 X min-1, p less than 0.01) at comparable insulin concentrations (92 +/- 6 versus 93 +/- 7 mU/l respectively). Thus, under conditions of hyperinsulinaemia, amino acids could compete with glucose as metabolic fuels.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Amino Acids / blood*
  • Amino Acids / metabolism
  • Female
  • Glucagon / blood
  • Glucose / metabolism*
  • Humans
  • Insulin / blood
  • Insulin / pharmacology*
  • Male
  • Middle Aged

Substances

  • Amino Acids
  • Insulin
  • Glucagon
  • Glucose