Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation

Elisabetta Citterio; Antonella Ellena Ronchi

doi:10.1002/1873-3468.14991

Deubiquitinases at the interplay between hematopoietic stem cell aging and myelodysplastic transformation

FEBS Lett. 2024 Aug 6. doi: 10.1002/1873-3468.14991. Online ahead of print.

Authors

Elisabetta Citterio¹, Antonella Ellena Ronchi¹

Affiliation

¹ Department of Biotechnology and Biosciences, University of Milano-Bicocca, 20126, Milan, Italy.

PMID: 39108012
DOI: 10.1002/1873-3468.14991

Abstract

Hematopoietic stem cells (HSC) maintain blood production throughout life. Nevertheless, HSC functionality deteriorates upon physiological aging leading to the increased prevalence of haematological diseases and hematopoietic malignancies in the elderly. Deubiquitinating enzymes (DUBs) by reverting protein ubiquitination ensure proper proteostasis, a key process in HSC maintenance and fitness.

Keywords: Acute Myeloid Leukemia (AML); Aging; Deubiquitinases; Deubiquitinating enzymes (DUBs); Hematopoietic Stem Cells (HSC); Myelodysplastic Syndromes (MDS); Ubiquitination.

Publication types

Review

Abstract

Publication types

Grants and funding