Dissecting Out a Rare Mutation, STAT: Features of STAT3-Mutant Myeloid Neoplasms

Clin Cancer Res. 2024 Oct 15;30(20):4554-4556. doi: 10.1158/1078-0432.CCR-24-1692.

Abstract

The transcription factor STAT3 drives the expression of genes promoting cellular proliferation, survival, and pluripotency. The description of STAT3 mutations and their clinical correlates in myeloid neoplasms, such as acute myeloid leukemia and myelodysplastic syndromes, raises new insights into both the pathogenesis and the targeted therapy of these diseases. See related article by Ye et al., p. 4681.

MeSH terms

  • Humans
  • Leukemia, Myeloid, Acute* / genetics
  • Leukemia, Myeloid, Acute* / pathology
  • Mutation*
  • Myelodysplastic Syndromes* / genetics
  • Myelodysplastic Syndromes* / pathology
  • STAT3 Transcription Factor* / genetics

Substances

  • STAT3 Transcription Factor
  • STAT3 protein, human