Serum concentration of cystatin C, factor D and beta 2-microglobulin as a measure of glomerular filtration rate

Acta Med Scand. 1985;218(5):499-503. doi: 10.1111/j.0954-6820.1985.tb08880.x.


Serum concentrations of creatinine and of the three low molecular weight (LMW) proteins cystatin C, factor D of the complement system and beta 2-microglobulin were measured in 135 consecutive patients, whose glomerular filtration rates (GFR) were determined by Cr-EDTA. In the total patient series, the reciprocals of S-creatinine and S-cystatin C were numerically and, in males, significantly more closely correlated to GFR than the reciprocals of S-factor D. The reciprocals of beta 2-microglobulin showed a weaker correlation to GFR than those of the other three substances. The calculated glomerular elimination rates of creatinine, cystatin C and factor D were normally distributed, in contrast to those of beta 2-microglobulin. According to data presented so far, cystatin C seems to be the LMW protein of first choice when GFR is to be estimated by measuring the plasma concentration of a LMW protein.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Blood Proteins*
  • Child
  • Complement Activating Enzymes / analysis*
  • Complement Factor D / analysis*
  • Cystatin C
  • Cystatins*
  • Female
  • Glomerular Filtration Rate*
  • Humans
  • Kidney Diseases / blood*
  • Kidney Diseases / physiopathology
  • Male
  • Middle Aged
  • Molecular Weight
  • Neoplasms / blood
  • Rheumatic Diseases / blood
  • Urologic Diseases / blood
  • beta 2-Microglobulin / analysis*


  • Blood Proteins
  • CST3 protein, human
  • Cystatin C
  • Cystatins
  • beta 2-Microglobulin
  • Complement Activating Enzymes
  • CFD protein, human
  • Complement Factor D