Comparison of propranolol and metoprolol in the management of hyperthyroidism

Br J Clin Pharmacol. 1979 Dec;8(6):581-7. doi: 10.1111/j.1365-2125.1979.tb01048.x.


1 Propranolol and metoprolol were both effective in controlling the symptoms and signs of hyperthyroidism. 2 Propranolol caused a highly significant increase in serum reverse T3 concentrations with lesser changes in other serum thyroid hormone levels, whereas metoprolol did not have this effect. 3 Steady-state plasma propranolol and metoprolol levels showed marked inter-individual variation. Metoprolol concentrations showed relatively little intra-individual variability, and could be related to the clinical efficacy of the drug, whereas no such relationship was demonstrated for propranolol.

Publication types

  • Clinical Trial
  • Comparative Study
  • Controlled Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Calcium / blood
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Hyperthyroidism / drug therapy*
  • Hyperthyroidism / physiopathology
  • Male
  • Metoprolol / adverse effects
  • Metoprolol / therapeutic use*
  • Middle Aged
  • Propanolamines / therapeutic use*
  • Propranolol / adverse effects
  • Propranolol / therapeutic use*
  • Time Factors


  • Propanolamines
  • Propranolol
  • Metoprolol
  • Calcium