[Toxic epidermal necrolysis (Lyell's syndrome) caused by piroxicam, with fatal outcome from disseminated aspergillosis]

Med Cutan Ibero Lat Am. 1985;13(4):291-300.
[Article in Spanish]

Abstract

A case of Lyell Syndrome provoked by ingestion of an antirheumatic drug (Piroxicam) is commented. The evolution under treatment with steroids and broad spectrum antibiotics was excellent but once recovered from this, the patient died subsequently to a systemic infectious process caused by an Aspergillosis with pulmonary involvement and secondary affectation of the kidneys, brain liver, and heart. The hepatic involvement during the acute stage is discussed and evaluated (increase of transaminases), amylasemia, amylasuria, anemia and thrombopenia which persisted throughout the process and presumably conditioned the evolution of the disease.

Publication types

  • Case Reports
  • English Abstract

MeSH terms

  • Anti-Inflammatory Agents, Non-Steroidal / adverse effects*
  • Aspergillosis / etiology
  • Humans
  • Male
  • Middle Aged
  • Piroxicam
  • Stevens-Johnson Syndrome / chemically induced*
  • Stevens-Johnson Syndrome / pathology
  • Thiazines / adverse effects*

Substances

  • Anti-Inflammatory Agents, Non-Steroidal
  • Thiazines
  • Piroxicam