The Impact of Low-Volume High-Intensity Interval Training (LV-HIIT) on Fatty Liver Index (FLI) and Estimated Glomerular Filtration Rate (eGFR) in Patients with Type 2 Diabetes Mellitus (T2DM)

Rasoul Raesi; Saeid Kalbasi; Abbas Ali Gaeini; Maryam Haji Ghasem Kashani; Khadijeh Tajik

doi:10.2174/0115733998320832240805113238

The Impact of Low-Volume High-Intensity Interval Training (LV-HIIT) on Fatty Liver Index (FLI) and Estimated Glomerular Filtration Rate (eGFR) in Patients with Type 2 Diabetes Mellitus (T2DM)

Curr Diabetes Rev. 2024 Aug 12. doi: 10.2174/0115733998320832240805113238. Online ahead of print.

Authors

Rasoul Raesi^{1

2}, Saeid Kalbasi³, Abbas Ali Gaeini⁴, Maryam Haji Ghasem Kashani⁵, Khadijeh Tajik⁶

Affiliations

¹ Department of Nursing, Torbat Jam Faculty of Medical Sciences, Torbat Jam, Iran.
² PhD in Health Services Management, Mashhad University of Medical Sciences, Mashhad, Iran.
³ Shahid Beheshti University of Medical Sciences Department of endocrinology, Loghman Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran Tehran Iran.
⁴ Department of Exercise Physiology, Faculty of Physical Education and Exercise Sciences, University of Tehran, Tehran, Iran.
⁵ Department of Cellular and Molecular Biology, School of Biology and Institute of Biological Sciences, Damghan University, Damghan, Iran.
⁶ Department of Physical Education and Sport Sciences, Alborz Pardis of Tehran University, Tehran, Iran.

PMID: 39136513
DOI: 10.2174/0115733998320832240805113238

Abstract

Background: Prevention and reduction of liver fat accumulation and maintenance of Glomerular Filtration Rate (GFR) have been proposed as important therapeutic goals in patients with Type 2 Diabetes Mellitus (T2DM).

Aim: This study aimed to determine the effect of Low-Volume High-Intensity Interval Training (LV-HIIT) on fatty liver index (FLI) and GFR estimation in patients with T2DM.

Methods: This randomized controlled trial included 80 patients with T2DM and a sedentary lifestyle, randomly divided into HIIT (n=40) and a control group (n=40). Patients with a history of T2DM for at least one year and HbA1C levels between 6.4% and 10% were selected. The intervention group underwent a 4-week LV-HIIT course, comprising 3 sessions per week, while the control group did not receive any intervention. FLI, eGFR, anthropometric measurements, and laboratory variables were assessed in all participants before and after the intervention.

Results: FLI (62.0 at baseline, 53.0 at follow-up) significantly decreased in the LV-HIIT group after the intervention, while eGFR (71.0 at baseline, 73.6 at follow-up) significantly increased (P<0.001). However, the control group showed a significant reduction only in Fasting Blood Sugar (FBS) (P<0.05). After the intervention, the LV-HIIT group had significantly lower FBS (129.0 at baseline, 121.0 at follow-up), Alanine Aminotransferase (ALT) (24.0 at baseline, 18.0 at follow-up), and Gamma-Glutamyl Transferase (GGT) (22.0 at baseline, 19.0 at follow-up), as well as higher eGFR, compared to the control group (P<0.05).

Conclusions: LV-HIIT exercise appears to be a promising and effective training method for improving FLI and eGFR in patients diagnosed with T2DM.

Keywords: Diabetes; estimated glomerular filtration Rate (eGFR); exercise; fasting blood sugar (FBS).; fatty liver Index (FLI); glomerulus; glycosylated hemoglobin (HbA1C); high-intensity interval training (HIIT); kidney; type 2 diabetes (T2DM).

Publication types

Clinical Trial