Bombesin effects on human GI functions

Peptides. 1985;6 Suppl 3:113-6. doi: 10.1016/0196-9781(85)90360-2.


In this article some of the actions of amphibian skin peptide Bombesin (BBS) on human gastrointestinal and pancreatic functions are reviewed. BBS causes increases of lower esophageal sphincter pressure, delay of gastric emptying, inhibition of mechanical activity of duodenum and jejunum and gallbladder emptying. BBS also releases in man gastrin and stimulates gastric acid secretion. BBS administration induces release of insulin, glucagon and pancreatic polypeptide from human Islet of Langerhans and causes secretion of pancreatic bicarbonates and enzymes in duodenal juice and release of pancreatic enzymes in blood stream.

MeSH terms

  • Bombesin / pharmacology*
  • Ceruletide / pharmacology
  • Digestive System / drug effects*
  • Gastric Juice / metabolism
  • Gastrins / metabolism
  • Gastrointestinal Motility / drug effects
  • Humans
  • Islets of Langerhans / metabolism
  • Pancreas / drug effects*
  • Pancreatic Juice / metabolism
  • Secretin / pharmacology
  • Secretory Rate / drug effects


  • Gastrins
  • Secretin
  • Ceruletide
  • Bombesin