No effect of vitamin B-6 against premenstrual tension. A controlled clinical study

Acta Obstet Gynecol Scand. 1985;64(8):667-70. doi: 10.3109/00016348509158211.


Vitamin B-6 100 mg given daily throughout the menstrual cycle was compared with placebo in a randomized, double-blind crossover trial in 34 women who suffered from premenstrual tension. Vitamin B-6 was no better than placebo. There was a substantial period effect, as the women evidenced a considerable preference for the second drug they received, irrespective of whether this was vitamin B-6 or placebo. Blood magnesium was measured; no significant difference was found between the 34 women with premenstrual tension and 10 healthy women without such complaints. Vitamin B-6 caused a small but statistically significant rise in blood magnesium level. In the individual patients, no correlation was found between changes in blood magnesium and premenstrual symptoms.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Magnesium / blood
  • Premenstrual Syndrome / blood
  • Premenstrual Syndrome / drug therapy*
  • Pyridoxine / therapeutic use*
  • Random Allocation


  • Magnesium
  • Pyridoxine