ZFP318 fuels memory B cells for success

Immunity. 2024 Aug 13;57(8):1723-1725. doi: 10.1016/j.immuni.2024.07.017.

Abstract

Diversity is a key feature of B cell biology-from BCR rearrangement to the heterogeneity of memory B cells. In this issue of Immunity, Wang et al. show that the zinc-finger protein ZFP318 supports mitochondrial health in certain memory B cells, thereby facilitating potent recall upon rechallenge.

Publication types

  • Comment

MeSH terms

  • Animals
  • B-Lymphocytes / immunology
  • DNA-Binding Proteins / immunology
  • DNA-Binding Proteins / metabolism
  • Humans
  • Immunologic Memory / immunology
  • Memory B Cells* / immunology
  • Mitochondria / immunology
  • Mitochondria / metabolism
  • Transcription Factors / immunology
  • Transcription Factors / metabolism

Substances

  • DNA-Binding Proteins
  • Transcription Factors