Macrophages dig into the obesity paradox in cancer

Christopher S Nabel; Florian Gourgue; Matthew G Vander Heiden

doi:10.1016/j.immuni.2024.07.013

Macrophages dig into the obesity paradox in cancer

Immunity. 2024 Aug 13;57(8):1731-1733. doi: 10.1016/j.immuni.2024.07.013.

Authors

Christopher S Nabel¹, Florian Gourgue², Matthew G Vander Heiden³

Affiliations

¹ Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Massachusetts General Hospital Cancer Center, Boston, MA, USA.
² Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA.
³ Koch Institute for Integrative Cancer Research, Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA; Dana-Farber Cancer Institute, Boston, MA, USA. Electronic address: mvh@mit.edu.

PMID: 39142274
DOI: 10.1016/j.immuni.2024.07.013

Abstract

Response to immune checkpoint blockade is increased in obesity-related cancers, but the mechanisms remain unclear. In a recent issue of Nature, Bader et al. report that obesity in mice induces macrophage PD-1 upregulation to promote tumor growth while potentiating immunotherapy responses.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
Humans
Immune Checkpoint Inhibitors / pharmacology
Immune Checkpoint Inhibitors / therapeutic use
Immunotherapy / methods
Macrophages* / immunology
Macrophages* / metabolism
Mice
Neoplasms* / etiology
Neoplasms* / immunology
Obesity Paradox
Obesity* / immunology
Programmed Cell Death 1 Receptor / metabolism

Substances

Programmed Cell Death 1 Receptor
Immune Checkpoint Inhibitors