Unlocking the potential of stimuli-responsive biomaterials for bone regeneration

Ke Yang; Zhuoshu Wu; Keke Zhang; Michael D Weir; Hockin H K Xu; Lei Cheng; Xiaojing Huang; Wen Zhou

doi:10.3389/fphar.2024.1437457

Unlocking the potential of stimuli-responsive biomaterials for bone regeneration

Front Pharmacol. 2024 Jul 31:15:1437457. doi: 10.3389/fphar.2024.1437457. eCollection 2024.

Authors

Ke Yang^{1

2}, Zhuoshu Wu^{1

2}, Keke Zhang³, Michael D Weir⁴, Hockin H K Xu⁴, Lei Cheng⁵, Xiaojing Huang^{1

2}, Wen Zhou^{1

2}

Affiliations

¹ Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterial & Stomatological Key Lab of Fujian College and University, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
² Clinical Research Center for Oral Tissue Deficiency Diseases of Fujian Province, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, China.
³ School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China.
⁴ Department of Biomaterials and Regenerative Dental Medicine, University of Maryland School of Dentistry, Baltimore, MD, United States.
⁵ State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China School of Stomatology & Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China.

Abstract

Bone defects caused by tumors, osteoarthritis, and osteoporosis attract great attention. Because of outstanding biocompatibility, osteogenesis promotion, and less secondary infection incidence ratio, stimuli-responsive biomaterials are increasingly used to manage this issue. These biomaterials respond to certain stimuli, changing their mechanical properties, shape, or drug release rate accordingly. Thereafter, the activated materials exert instructive or triggering effects on cells and tissues, match the properties of the original bone tissues, establish tight connection with ambient hard tissue, and provide suitable mechanical strength. In this review, basic definitions of different categories of stimuli-responsive biomaterials are presented. Moreover, possible mechanisms, advanced studies, and pros and cons of each classification are discussed and analyzed. This review aims to provide an outlook on the future developments in stimuli-responsive biomaterials.

Keywords: bone regeneration; composites; hydrogels; implants; scaffolds; stimuli-responsive biomaterials.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This work was supported by the Joint Funds for the innovation of science and Technology, Fujian province (Grant number: 2021Y9026), Introduced Talents Grant of School and Hospital of Stomatology Fujian Medical University (Grant number: 2023KQYJ01), and Joint Funds for the innovation of science and Technology, Fujian province (Grant number: 2023Y9223).