Novel pathomechanistic insights into lysosomal storage disorders: how neuron-intrinsic cGAS-STING signaling drives disease progression

Signal Transduct Target Ther. 2024 Aug 16;9(1):203. doi: 10.1038/s41392-024-01901-5.

Authors

Maximilian Frosch¹, Marco Prinz^{2

3}

Affiliations

¹ Institute of Neuropathology, University of Freiburg, Faculty of Medicine, Freiburg, Germany.
² Institute of Neuropathology, University of Freiburg, Faculty of Medicine, Freiburg, Germany. marco.prinz@uniklinik-freiburg.de.
³ Signalling Research Centres BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. marco.prinz@uniklinik-freiburg.de.

No abstract available

MeSH terms

Animals
Disease Progression
Humans
Lysosomal Storage Diseases* / genetics
Lysosomal Storage Diseases* / metabolism
Lysosomal Storage Diseases* / pathology
Membrane Proteins* / genetics
Membrane Proteins* / metabolism
Neurons* / metabolism
Neurons* / pathology
Nucleotidyltransferases* / genetics
Nucleotidyltransferases* / metabolism
Signal Transduction* / genetics

Substances

Nucleotidyltransferases
Membrane Proteins
STING1 protein, human
cGAS protein, human