Role and mechanisms of autophagy, ferroptosis, and pyroptosis in sepsis-induced acute lung injury

Yao Shen; Yingying He; Ying Pan; Li Liu; Yulin Liu; Jing Jia

doi:10.3389/fphar.2024.1415145

Role and mechanisms of autophagy, ferroptosis, and pyroptosis in sepsis-induced acute lung injury

Front Pharmacol. 2024 Aug 5:15:1415145. doi: 10.3389/fphar.2024.1415145. eCollection 2024.

Authors

Yao Shen^#^{1

2}, Yingying He^#^{1

2}, Ying Pan^#^{1

2}, Li Liu^{1

2}, Yulin Liu^{1

2}, Jing Jia^{1

2}

Affiliations

¹ Department of Anesthesiology, The Affiliated Hospital, Southwest Medical University, Luzhou, China.
² Anesthesiology and Critical Care Medicine Key Laboratory of Luzhou, The Affiliated Hospital, Southwest Medical University, Luzhou, China.

^# Contributed equally.

Abstract

Sepsis-induced acute lung injury (ALI) is a major cause of death among patients with sepsis in intensive care units. By analyzing a model of sepsis-induced ALI using lipopolysaccharide (LPS) and cecal ligation and puncture (CLP), treatment methods and strategies to protect against ALI were discussed, which could provide an experimental basis for the clinical treatment of sepsis-induced ALI. Recent studies have found that an imbalance in autophagy, ferroptosis, and pyroptosis is a key mechanism that triggers sepsis-induced ALI, and regulating these death mechanisms can improve lung injuries caused by LPS or CLP. This article summarized and reviewed the mechanisms and regulatory networks of autophagy, ferroptosis, and pyroptosis and their important roles in the process of LPS/CLP-induced ALI in sepsis, discusses the possible targeted drugs of the above mechanisms and their effects, describes their dilemma and prospects, and provides new perspectives for the future treatment of sepsis-induced ALI.

Keywords: acute lung injury (ALI); autophagy; ferroptosis; pyroptosis; sepsis.

Publication types

Review

Grants and funding

The author(s) declare that financial support was received for the research, authorship, and/or publication of this article. This study was supported by National Natural Science Foundation of China (Grant No. 82000052), Sichuan Science and Technology Program (Grant No. 2022YFS0632), the joint foundation of Luzhou Government and Southwest Medical University (No. 2021LZXNYD-J25).