Diet, butyric acid and differentiation of gastrointestinal tract tumours

Med Hypotheses. 1985 Oct;18(2):113-8. doi: 10.1016/0306-9877(85)90043-x.


Butyric acid has two contrasting functional roles. As a product of fermentation within the human colon, it serves as the most important energy source for normal colorectal epithelium. It also promotes the differentiation of cultured malignant cells. A switch from aerobic to anaerobic metabolism accompanies neoplastic transformation in the colorectum. The separate functional roles for n-butyrate may reflect the different metabolic activities of normal and neoplastic tissues. Relatively low intracolonic levels of n-butyrate are associated with a low fibre diet. Deficiency of n-butyrate, coupled to the increased energy requirements of neoplastic tissues, may promote the switch to anaerobic metabolism. The presence of naturally occurring differentiating agents, such as n-butyrate, may modify the patterns of growth and differentiation of gastrointestinal tumours.

MeSH terms

  • Butyrates / metabolism*
  • Cell Transformation, Neoplastic / metabolism*
  • Fermentation
  • Humans
  • Intestinal Neoplasms / metabolism*
  • Tumor Cells, Cultured / metabolism


  • Butyrates