Epigenetic Therapy in a Rare Ovarian Cancer - A Double-Edged Sword

N Engl J Med. 2024 Aug 22;391(8):770-772. doi: 10.1056/NEJMc2407971.
No abstract available

Publication types

  • Case Reports
  • Letter

MeSH terms

  • Adult
  • Antineoplastic Agents* / administration & dosage
  • Antineoplastic Agents* / adverse effects
  • Benzamides
  • Biphenyl Compounds
  • DNA Helicases / genetics
  • DNA Methylation
  • Enhancer of Zeste Homolog 2 Protein / antagonists & inhibitors
  • Epigenesis, Genetic* / drug effects
  • Female
  • Humans
  • Morpholines
  • Neoplasms, Second Primary* / diagnosis
  • Neoplasms, Second Primary* / genetics
  • Nuclear Proteins / genetics
  • Ovarian Neoplasms* / diagnosis
  • Ovarian Neoplasms* / genetics
  • Ovarian Neoplasms* / therapy
  • Ovariectomy
  • Ovary / pathology
  • Ovary / surgery
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / diagnosis
  • Precursor T-Cell Lymphoblastic Leukemia-Lymphoma* / genetics
  • Pyridones
  • Rare Diseases* / diagnosis
  • Rare Diseases* / genetics
  • Rare Diseases* / therapy
  • Synthetic Lethal Mutations / drug effects
  • Transcription Factors / genetics

Substances

  • DNA Helicases
  • Nuclear Proteins
  • Transcription Factors
  • Enhancer of Zeste Homolog 2 Protein
  • Antineoplastic Agents
  • SMARCA4 protein, human
  • EZH2 protein, human
  • tazemetostat
  • Benzamides
  • Biphenyl Compounds
  • Morpholines
  • Pyridones