A core proteome profile unites mouse models and patients in Alzheimer disease

Grigoria Tsaka; Frederic Rousseau; Joost Schymkowitz

doi:10.1016/j.xcrm.2024.101683

A core proteome profile unites mouse models and patients in Alzheimer disease

Cell Rep Med. 2024 Aug 20;5(8):101683. doi: 10.1016/j.xcrm.2024.101683.

Authors

Grigoria Tsaka¹, Frederic Rousseau², Joost Schymkowitz²

Affiliations

¹ Switch Laboratory, VIB Center for Brain and Disease Research, Leuven, Belgium; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium; Laboratory for Neuropathology, Department of Imaging and Pathology, KU Leuven, Leuven, Belgium; Leuven Brain Institute, KU Leuven, Leuven, Belgium. Electronic address: grigoria.tsaka@kuleuven.be.
² Switch Laboratory, VIB Center for Brain and Disease Research, Leuven, Belgium; Switch Laboratory, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium.

Abstract

Levites et al. demonstrate that mouse models of Alzheimer disease (AD), exhibiting amyloid-beta (Αβ) plaque formation, share Αβ responsome proteins with humans. Their work underscores the value of these models in studying Αβ aggregation, cellular vulnerability, and early-stage AD pathology.

MeSH terms

Alzheimer Disease* / genetics
Alzheimer Disease* / metabolism
Alzheimer Disease* / pathology
Amyloid beta-Peptides / metabolism
Animals
Disease Models, Animal*
Humans
Mice
Plaque, Amyloid / metabolism
Plaque, Amyloid / pathology
Proteome* / metabolism

Substances

Proteome
Amyloid beta-Peptides