Natural progesterone and antihypertensive action

Br Med J (Clin Res Ed). 1985 Jan 5;290(6461):13-4. doi: 10.1136/bmj.290.6461.13.


In a placebo controlled, double blind crossover study natural progesterone was given by mouth, in increasing doses, to six men and four postmenopausal women with mild to moderate hypertension who were not receiving any other antihypertensive drugs. When compared with values recorded before treatment and during administration of placebo progesterone caused a significant reduction in blood pressure, suggesting that progesterone has an antihypertensive action rather than a hypertensive one as has been previously thought. This possible protective effect of progesterone should be investigated further.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Clinical Trials as Topic
  • Double-Blind Method
  • Female
  • Humans
  • Hypertension / drug therapy*
  • Male
  • Menopause
  • Middle Aged
  • Posture
  • Progesterone / therapeutic use*


  • Progesterone