The effect of short-term oxygen supplementation on oxygen hemoglobin affinity in patients with chronic obstructive pulmonary disease

Am Rev Respir Dis. 1985 Jan;131(1):69-72. doi: 10.1164/arrd.1985.131.1.69.

Abstract

In 12 hypoxemic patients with chronic obstructive pulmonary disease, the partial pressure of oxygen at which hemoglobin is 50% saturated (P50) and levels of 2,3-diphosphoglycerate (2,3-DPG) were determined under 3 study conditions: (1) while breathing room air, (2) during oxygen supplementation for 72 h sufficient to increase PaO2 above 70 mmHg, and (3) at 72 h after the period of oxygen supplementation. The data showed that in the control period in hypoxemic (PaO2, 52 +/- 6 mmHg), mildly hypercapnic (PaCO2, 47 +/- 6 mmHg) patients with a borderline elevation of pH (7.42 +/- 0.03), there was an increase in P50 (28.6 +/- 1.6 versus a normal value of 26.5 +/- 1; p less than 0.005), and a concomitant increase in 2,3-DPG (19.02 +/- 1.77 mg/g Hb versus a normal value of 13.52 +/- 1.27; p less than 0.005). Nine patients received oxygen for 24 h, and 5 received oxygen for 72 h. In these 5 patients, oxygen supplementation resulted in a shift in P50 to a normal value of 26.7 +/- 1.8 (this value was different from the patients' level while breathing room air and not different from that of the normoxemic control subjects) and a decrease in 2,3-DPG toward but not to a normal value (16.34 +/- 1.92; p less than 0.01). This shift in P50 to the left could be related to the decrease in 2,3-DPG. Accordingly, in patients with COPD who are treated with supplemental oxygen, the net effect on oxygen transport would be a function of the changes produced in PaO2 versus those in hemoglobin-oxygen affinity.(ABSTRACT TRUNCATED AT 250 WORDS)

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • 2,3-Diphosphoglycerate
  • Arteries
  • Carbon Dioxide / blood
  • Diphosphoglyceric Acids / blood
  • Erythrocytes / metabolism
  • Hemoglobins / metabolism*
  • Humans
  • Lung Diseases, Obstructive / blood
  • Lung Diseases, Obstructive / drug therapy*
  • Male
  • Oxygen / administration & dosage*
  • Oxygen / blood
  • Oxygen / therapeutic use
  • Partial Pressure
  • Time Factors

Substances

  • Diphosphoglyceric Acids
  • Hemoglobins
  • 2,3-Diphosphoglycerate
  • Carbon Dioxide
  • Oxygen