[Randomized controlled trial of postoperative adjuvant chemotherapy with bestatin for gastric cancer]

Gan To Kagaku Ryoho. 1985 Jan;12(1):125-33.
[Article in Japanese]


The effectiveness of Bestatin on the prognosis of gastric cancer patients was investigated in a randomized controlled trial of postoperative adjuvant chemotherapy. One hundred and sixty-two cases of gastrectomized patients were divided into two groups; a Bestatin group (83 cases, 1/2MF'C [mitomycin C 2 mg and cytosine arabinoside 20 mg i.v. twice a week for 3 weeks, FT-207 400 mg/day i.v. for 3 weeks] followed by Bestatin 30 mg/day and FT-207 0.6 g/day p.o.) and a control group (79 cases, 1/2MF'C followed by FT-207 alone). No significant differences in background factors between the two groups were found. Bestatin was slightly effective in improving the three-year survival rates of gastric cancer patients, but this was not significant. However, survival rates in the Bestatin group in Stage II, curatively operated cases, and n (-) ps (+) cases were significantly higher than those of the control group during the same postoperative period. Bestatin prolonged the disease-free interval in curatively resected cases. Thus, efficacy of Bestatin in improving survival rates was observed in the early stages of disease, but it is suggested that combination a stronger chemotherapeutic regimen may be effective in advanced cases.

Publication types

  • Clinical Trial
  • English Abstract
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Antibiotics, Antineoplastic / therapeutic use*
  • Antineoplastic Combined Chemotherapy Protocols / therapeutic use
  • Clinical Trials as Topic
  • Cytarabine / administration & dosage
  • Female
  • Gastrectomy
  • Humans
  • Leucine / analogs & derivatives*
  • Leucine / therapeutic use
  • Male
  • Middle Aged
  • Mitomycin
  • Mitomycins / administration & dosage
  • Postoperative Care
  • Prognosis
  • Random Allocation
  • Stomach Neoplasms / drug therapy*
  • Stomach Neoplasms / mortality
  • Stomach Neoplasms / surgery
  • Tegafur / administration & dosage


  • Antibiotics, Antineoplastic
  • Mitomycins
  • Cytarabine
  • Tegafur
  • Mitomycin
  • Leucine
  • ubenimex