Analysis of the function, mechanism and clinical application prospect of TRPS1, a new marker for breast cancer

Gene. 2025 Jan 10:932:148880. doi: 10.1016/j.gene.2024.148880. Epub 2024 Aug 23.

Abstract

It has been discovered that Trichorhinophalangeal Syndrome-1 (TRPS1), a novel member of the GATA transcription factor family, participates in both normal physiological processes and the development of numerous diseases. Recently, TRPS1 has been identified as a new biomarker to aid in cancer diagnosis and is very common in breast cancer (BC), especially in triple-negative breast cancer (TNBC). In this review, we discussed the structure and function of TRPS1 in various normal cells, focused on its role in tumorigenesis and tumor development, and summarize the research status of TRPS1 in the occurrence and development of BC. We also analyzed the potential use of TRPS1 in guiding clinically personalized precision treatment and the development of targeted drugs.

Keywords: Cancer; GATA; Oncogene; Transcriptional factor; Trichorhinophalangeal Syndrome-1.

Publication types

  • Review

MeSH terms

  • Animals
  • Biomarkers, Tumor* / genetics
  • Biomarkers, Tumor* / metabolism
  • Breast Neoplasms* / diagnosis
  • Breast Neoplasms* / genetics
  • Breast Neoplasms* / metabolism
  • Carcinogenesis / genetics
  • Carcinogenesis / metabolism
  • DNA-Binding Proteins* / genetics
  • DNA-Binding Proteins* / metabolism
  • Female
  • Gene Expression Regulation, Neoplastic
  • Humans
  • Repressor Proteins* / genetics
  • Repressor Proteins* / metabolism
  • Transcription Factors* / genetics
  • Transcription Factors* / metabolism
  • Triple Negative Breast Neoplasms / genetics
  • Triple Negative Breast Neoplasms / metabolism

Substances

  • TRPS1 protein, human
  • Biomarkers, Tumor
  • Transcription Factors
  • DNA-Binding Proteins
  • Repressor Proteins