Immunohistochemical studies of interleukin-2 and gamma-interferon in rheumatoid arthritis

Arthritis Rheum. 1985 Feb;28(2):174-81. doi: 10.1002/art.1780280212.


Synovial tissues were studied, using immunofluorescence techniques, for localization of lymphocytic infiltrates and immune reactants, including C3, C5b-9, C9, and Ia antigen. Tissue distribution of interleukin-2 (IL-2) and gamma-interferon was also determined, using mouse monoclonal antibodies. IL-2 was found in association with OKT8 and OKT4 T cells, and gamma-interferon was noted in association with T cells, B cells, and macrophages. Staining both for IL-2 and for gamma-interferon was surprisingly faint in view of the intensity of lymphocytic infiltration.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Arthritis, Rheumatoid / metabolism*
  • Fluorescent Antibody Technique
  • Humans
  • Interferon-gamma / analysis*
  • Interleukin-2 / analysis*
  • Macrophages / immunology
  • Synovial Membrane / analysis
  • T-Lymphocytes / immunology
  • Tissue Distribution


  • Interleukin-2
  • Interferon-gamma