Abstract
We herein report a "Fight Aggregation with Aggregation" (FAA) approach for redirection of amyloid-β peptide (Aβ) aggregation using a europium(III) complex (EuL3) that can undergo H-aggregation in aqueous solution under physiological conditions. The H-aggregates of EuL3 may serve as scaffolds that can facilitate the accumulation of Aβ to form non-fibrillar co-assemblies. As a result, the Aβ aggregation-induced cytotoxicity was inhibited.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amyloid beta-Peptides* / chemistry
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Amyloid beta-Peptides* / metabolism
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Animals
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Cell Survival / drug effects
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Coordination Complexes* / chemical synthesis
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Coordination Complexes* / chemistry
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Coordination Complexes* / pharmacology
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Europium* / chemistry
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Europium* / pharmacology
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Humans
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Protein Aggregates* / drug effects
Substances
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Europium
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Amyloid beta-Peptides
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Coordination Complexes
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Protein Aggregates