Role of Rab GTPases in Bacteria Escaping from Vesicle Trafficking of Host Cells

Abstract

Most bacteria will use their toxins to interact with the host cell, causing damage to the cell and then escaping from it. When bacteria enter the cell, they will be transported via the endosomal pathway. Rab GTPases are involved in bacterial transport as major components of endosomes that bind to their downstream effector proteins. The bacteria manipulate some Rab GTPases, escape the cell, and get to survive. In this review, we will focus on summarizing the many processes of how bacteria manipulate Rab GTPases to control their escape.

Keywords: Bacteria; Escape; Host; Rab GTPases; Toxins; Vesicle trafficking.